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Pragmatic trials are those that are designed to provide information for real-world clinical practice. They are typically characterized by a focus on the practical aspects of research design, like recruitment and consent in adherence, as well as the use of standard equipment.

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A pragmatic study that involves different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. Too much heterogeneity, however could cause issues with the trial design.

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The purpose of pragmatic trials is to mimic real-life scenarios and gain maximum credibility externally. They are usually commissioned by practitioners and policy makers to inform their decision making. They can also be used to determine the cause-effect relationship of an intervention and its results. However, they should not be used in lieu for the use of explanation trials.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace or 프라그마틱 슬롯 무료체험 complement them. Schwartz and Lellouch1 made a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a pragmatic study that include recruitment, design and delivery of the intervention, and the follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) produced 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to remember, however, that the majority of studies were conducted in primary care settings.